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Ticoflex SR 500mg Tablet 1 Strip
Naproxen is used to relieve pain and inflammation in:
- Rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
- Juvenile rheumatoid arthritis
- Tendonitis and bursitis
- Acute gout
- Primary dysmenorrhea (menstrual pain)
- General pain relief
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✅ Description:
Naproxen is a Non-Steroidal Anti-Inflammatory Drug (NSAID) with:
- Analgesic (pain-relieving)
- Anti-inflammatory
- Antipyretic (fever-reducing) properties
Absorption is rapid, with 95% bioavailability.
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✔️ Dosage & Administration of Ticoflex SR 500
🔸 Adults:
Arthritis (RA, OA, AS):
- 500–1000 mg/day in 2 divided doses after meals
Pain, Dysmenorrhea, Tendonitis, Bursitis:
- Initial: 500 mg
- Then: 500 mg every 12 hrs OR 250 mg every 6–8 hrs
- Max first-day dose: 1250 mg, afterward ≤1000 mg/day
Acute Gout:
- Start: 750 mg
- Then: 250 mg every 8 hrs until symptoms improve
🔹 Children (Juvenile Rheumatoid Arthritis):
Over 2 years:
- 10 mg/kg/day in 2 divided doses (12-hr interval)
Under 2 years: Not recommended
✔️ Drug Interactions
- 🚫 Lithium: Naproxen reduces lithium excretion → Possible toxicity
- 🔽 Antihypertensives: These may reduce their effectiveness
- ⚠️ Aminoglycosides (e.g., Gentamicin): May increase levels → risk of side effects
- ❌ Anticoagulants (e.g., Warfarin): Increased bleeding risk due to dual blood thinning
✔️ Contraindications
- Allergy to naproxen, aspirin, or other NSAIDs
- History of NSAID-induced asthma, urticaria, or anaphylaxis
- Perioperative pain after coronary artery bypass graft (CABG) surgery
✔️ Side Effects of Ticoflex SR 500
- Rash, headache, dizziness, drowsiness
- Tinnitus (ringing in the ears)
- Stomach issues: pain, nausea, diarrhea, constipation, heartburn
- Fluid retention, shortness of breath
- Stomach/intestinal ulcers and bleeding
✔️ Pregnancy & Lactation
- Pregnancy Category C: Avoid, especially in late pregnancy (may cause ductus arteriosus closure)
- Not recommended for nursing mothers due to potential risk to the infant
✔️ Storage
- Keep below 30°C, in a cool, dry, light-protected place
- Keep out of children's reach
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